Clinical implications of the ENCODE project
نویسندگان
چکیده
منابع مشابه
Clinical implications of the ENCODE project.
The first results of the ENCODE (Encyclopedia of DNA Elements) project have been recently presented in 30 articles published in Nature, Genome Research and Genome Biology (see for example the article published in Nature 489, pp 57–74, by the ENCODE Project Consortium, related articles in the same issue of Nature and references therein). These articles present the results obtained by the collabo...
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Two clichés of science journalism have now played out around the ENCODE project. ENCODE's publicity first presented a misleading "all the textbooks are wrong" narrative about noncoding human DNA. Now several critiques of ENCODE's narrative have been published, and one was so vitriolic that it fueled "undignified academic squabble" stories that focused on tone more than substance. Neither story ...
متن کاملThe ENCODE Project at UC Santa Cruz
The goal of the Encyclopedia Of DNA Elements (ENCODE) Project is to identify all functional elements in the human genome. The pilot phase is for comparison of existing methods and for the development of new methods to rigorously analyze a defined 1% of the human genome sequence. Experimental datasets are focused on the origin of replication, DNase I hypersensitivity, chromatin immunoprecipitati...
متن کاملGENCODE: the reference human genome annotation for The ENCODE Project.
The GENCODE Consortium aims to identify all gene features in the human genome using a combination of computational analysis, manual annotation, and experimental validation. Since the first public release of this annotation data set, few new protein-coding loci have been added, yet the number of alternative splicing transcripts annotated has steadily increased. The GENCODE 7 release contains 20,...
متن کاملThe implications of alternative splicing in the ENCODE protein complement.
Alternative premessenger RNA splicing enables genes to generate more than one gene product. Splicing events that occur within protein coding regions have the potential to alter the biological function of the expressed protein and even to create new protein functions. Alternative splicing has been suggested as one explanation for the discrepancy between the number of human genes and functional c...
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ژورنال
عنوان ژورنال: Clinical and Translational Oncology
سال: 2012
ISSN: 1699-048X,1699-3055
DOI: 10.1007/s12094-012-0958-0